$223 Cheap flight deals from Columbia (CAE) to Key West (EYW)

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This Weekend's Flight Deals from Columbia to Key West

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, May 3 - Thu, May 8
CAE
Columbia Metropolitan
EYW
Key West Intl.
$474 Roundtrip, found 22 hours ago
$474
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Sat, May 3 from Columbia Metropolitan to Key West Intl., returning Thu, May 8, priced at $474 found 22 hours ago

Airfares from $223 One Way, $253 Round Trip from Columbia to Key West

Prices starting at $253 for return flights and $223 for one-way flights to Key West were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Jun 16 - Tue, Jun 24
CAE
Columbia
EYW
Key West
$253 Roundtrip, found 4 days ago
$253
Roundtrip
found 4 days ago
Select Delta flight, departing Mon, Jun 16 from Columbia to Key West, returning Tue, Jun 24, priced at $253 found 4 days ago
Tue, May 6 - Wed, May 14
CAE
Columbia
EYW
Key West
$258 Roundtrip, found 3 days ago
$258
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, May 6 from Columbia to Key West, returning Wed, May 14, priced at $258 found 3 days ago
Mon, May 5 - Wed, May 14
CAE
Columbia
EYW
Key West
$319 Roundtrip, found 3 days ago
$319
Roundtrip
found 3 days ago
Select Delta flight, departing Mon, May 5 from Columbia to Key West, returning Wed, May 14, priced at $319 found 3 days ago
Fri, Jun 13 - Fri, Jun 20
CAE
Columbia
EYW
Key West
$385 Roundtrip, found 4 days ago
$385
Roundtrip
found 4 days ago
Select Delta flight, departing Fri, Jun 13 from Columbia to Key West, returning Fri, Jun 20, priced at $385 found 4 days ago
Mon, Jun 16 - Fri, Jun 20
CAE
Columbia
EYW
Key West
$394 Roundtrip, found 4 days ago
$394
Roundtrip
found 4 days ago
Select Delta flight, departing Mon, Jun 16 from Columbia to Key West, returning Fri, Jun 20, priced at $394 found 4 days ago

Key West economy flight packages

Price found within the past 48 hours. Click for updated prices.
Hyatt Vacation Club at Windward Pointe, Key West
3.5-star property

Hyatt Vacation Club at Windward Pointe, Key West

9.4/10 Exceptional! (1,005 reviews)

Jun 20 - Jun 23

3 night stay

Columbia (CAE) to Key West (EYW)

Delta • Non-stop roundtrip • Coach
per person
found 1 day ago
Wonderful pool area!! Very spacious! Beautiful views! Very clean and spacious rooms! Right next to the airport. 10 min car ride to downtown.

Reviewed on Apr 15, 2025

Southernmost Beach Resort
4.0-star property

Southernmost Beach Resort

8.6/10 Excellent! (2,353 reviews)

Jun 20 - Jun 23

3 night stay

Columbia (CAE) to Key West (EYW)

Delta • Non-stop roundtrip • Coach
per person
found 1 day ago
I really enjoyed my long weekend at the Southernmost Beach Resort. There are several pools, beaches, bars and a restaurant. My room was clean and spacious. All the staff I encountered were super friendly. Great location and easy walking distance to Duval.

Reviewed on Apr 1, 2025

Pier House Resort & Spa
4.0-star property

Pier House Resort & Spa

9/10 Wonderful! (1,006 reviews)

Jun 20 - Jun 23

3 night stay

Columbia (CAE) to Key West (EYW)

Delta • Non-stop roundtrip • Coach
per person
found 1 day ago
Enjoyed this property for our Honeymoon. Stayed in a Traditional King Room, however, was wanting a better view then just the courtyard. The staff was excellent!!! Linda out by the bar and beach - she rocks !!! Best server around!!! Will return in the future.

Reviewed on Feb 20, 2025

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More About Flying To Key West from Columbia

Route Information for Flights from Columbia to Key West

Origin Airport IATA Code
CAE
Destination Airport IATA Code
EYW
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Columbia to Key West

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Frequently asked questions

Am I able to catch a flight from Columbia to Key West now?
If you’re puzzled about travel restrictions and quarantine requirements when getting a flight from Columbia to Key West, go right to our Covid-19 Travel Advisor.
What is the shortest flight from Columbia to Key West?
It can take just 2 hours and 39 minutes to travel from Columbia, SC Airport (CAE-Columbia Metropolitan) to Key West Intl. Airport. Relax and enjoy the journey, because you’ll be landing in the blink of an eye.
If I am not able to travel due to COVID-19, can I cancel my flight to Key West?
We get that traveling right now has its challenges, so it’s good to know that many reservations booked through us are able to be cancelled or changed. If your travel plans to Key West have been affected by COVID-19, a lot of airlines are making things easier by offering credits to use at a later date. Just sign in to your account and you’ll quickly see what options are available. Our Customer Service Portal is the place to go for more information.
Are there flights to Key West with flexible change policies?
In most cases you’ll have the option to reschedule your flight to Key West without a change fee. All you have to do then is pay the difference between the old flight and the new one. Look for the “no change fees” filter and book with confidence.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2020 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won’t keep you guessing, according to Orbitz data the cheapest month to fly is August. Perfect for those who need a weekend getaway, or just a break from it all before the weather changes. Be aware that the most expensive time to fly is the height of summer, with ticket prices peaking in the month of June.
How can I save money on flights?
To really save big on your next vacation, think outside the box. Select two different airlines or fare types for your return trip and you’ll generally get a much better deal. Those who tried this on Orbitz in 2020 saved up to 45% on their airfares. Get mixing and matching today!

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.