$143 Cheap flight deals from St. Louis (STL) to Port Saint Lucie (PBI)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

This Weekend's Flight Deals from St. Louis to Port Saint Lucie

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Airfares from $143 One Way, $319 Round Trip from St. Louis to Port Saint Lucie

Prices starting at $319 for return flights and $143 for one-way flights to Port Saint Lucie were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Port Saint Lucie economy flight packages

Price found within the past 48 hours. Click for updated prices.
Hutchinson Island Hotel
Marriott Hutchinson Island Beach Resort, Golf & Marina
Don't see what you're looking for?
See all available trips from St. Louis to Port Saint Lucie
View all trips

More About Flying To Port Saint Lucie from St. Louis

Route Information for Flights from St. Louis to Port Saint Lucie

Origin Airport IATA Code
STL
Destination Airport IATA Code
PBI
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

St. Louis to Port Saint Lucie

Orbitz On-the-Go is your one-stop shop for discount vacation air travel. Our cutting-edge mobile tools leave you time to pack for the trip. Shop our sales on domestic flights from St. Louis to Port Saint Lucie.

Best Bargains Anywhere

Cheap vacations start at Orbitz On-the-Go. Find the best deals on international flights from St. Louis to Port Saint Lucie.

Complete Travel Planning

Your phone becomes a full-service vacation travel agency with Orbitz mobile phone apps. From reservations to arrivals, every detail is in the palm of your hand. Book budget flights from St. Louis to Port Saint Lucie; add a car and hotel, share your itinerary and keep up with changes. Orbitz apps cover all the bases for you.

Totally Stress-Free

Free Alerts from Orbitz On-the-Go keep your vacation free from worry. Free Alerts updates you the moment any changes occur. You’ll always have the most current flight, gate and baggage claim details. So sit back and enjoy your low fare on St. Louis to Port Saint Lucie flights.

More Miles Faster = Maximum Value

Orbitz On-the-Go securely stores your frequent flier and loyalty program information. Watch your miles add up when you book discount St. Louis to Port Saint Lucie flights with Orbitz. Make your vacation mileage-friendly with low cost air tickets on St. Louis to Port Saint Lucie flights. Orbitz is your destination for vacation value.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.