$144 Cheap flight deals from Panama City (PNS) to Knoxville (TYS)

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This Weekend's Flight Deals from Panama City to Knoxville

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, May 3 - Sun, May 4
VPS
Northwest Florida Regional
TYS
McGhee Tyson
$432 Roundtrip, found 5 days ago
$432
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sat, May 3 from Northwest Florida Regional to McGhee Tyson, returning Sun, May 4, priced at $432 found 5 days ago

Airfares from $144 One Way, $285 Round Trip from Panama City to Knoxville

Prices starting at $285 for return flights and $144 for one-way flights to Knoxville were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, May 25 - Thu, May 29
VPS
Fort Walton Beach
TYS
Knoxville
$285 Roundtrip, found 2 days ago
$285
Roundtrip
found 2 days ago
Select Delta flight, departing Sun, May 25 from Fort Walton Beach to Knoxville, returning Thu, May 29, priced at $285 found 2 days ago
Wed, May 21 - Wed, May 28
PNS
Pensacola
TYS
Knoxville
$291 Roundtrip, found 2 days ago
$291
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, May 21 from Pensacola to Knoxville, returning Wed, May 28, priced at $291 found 2 days ago
Sun, May 25 - Tue, Jun 3
VPS
Fort Walton Beach
TYS
Knoxville
$315 Roundtrip, found 2 days ago
$315
Roundtrip
found 2 days ago
Select Delta flight, departing Sun, May 25 from Fort Walton Beach to Knoxville, returning Tue, Jun 3, priced at $315 found 2 days ago
Sun, May 25 - Sun, Jun 1
VPS
Fort Walton Beach
TYS
Knoxville
$325 Roundtrip, found 2 days ago
$325
Roundtrip
found 2 days ago
Select Delta flight, departing Sun, May 25 from Fort Walton Beach to Knoxville, returning Sun, Jun 1, priced at $325 found 2 days ago
Wed, May 14 - Sat, May 17
PNS
Pensacola
TYS
Knoxville
$328 Roundtrip, found 2 days ago
$328
Roundtrip
found 2 days ago
Select United flight, departing Wed, May 14 from Pensacola to Knoxville, returning Sat, May 17, priced at $328 found 2 days ago

More About Flying To Knoxville from Panama City

Route Information for Flights from Panama City to Knoxville

Origin Airport IATA Code
PNS
Destination Airport IATA Code
TYS
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Panama City to Knoxville

Whether you want to book cheap flights from Panama City to Knoxville or are looking for the perfect package holiday, Orbitz is your one-stop source. Taking the stress and expense out of travel, Orbitz helps you find the best fares for Panama City to Knoxville flights.

Make the Most of Your Vacation

Not only does Orbitz have cheap deals for Panama City to Knoxville flights, we can also help you plan your vacation in advance. Why wait in lengthy lines for tickets to shows, amusement parks, and other attractions when you could be making the most of your holiday? Add activities to your flight booking for fewer hassles once you arrive in Knoxville.

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Book your flights from Panama City to Knoxville wherever you are with the Orbitz app for Android and iPhone. Or simply use m.orbitz.com on your mobile browser to search and book the Panama City to Knoxville flights that you want. And if you’re running late, you check your flight status and baggage claim information on your mobile device too too.

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Keep Informed With Orbitz

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Frequently asked questions

Are there non-stop flights from Panama City to Knoxville?
Allegiant Air will fly you nonstop from Northwest Florida Regional Airport (VPS) to McGhee Tyson Airport (TYS), which means you won’t have to stress about swapping planes or missing your connection on this route.
What is the shortest flight from Panama City to Knoxville?
If conditions are good and there are no delays, you could be stepping off the plane at TYS from Pensacola Airport in only 1 hour and 58 minutes. With such a brief flight time, think about bringing hand luggage only.
What airlines fly from Panama City to Knoxville most frequently?
Allegiant Air is the most frequent flyer along this route. This top-rated carrier operates 8 flights from Destin–Fort Walton Beach Airport to Knoxville Airport every month.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won’t keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.