Southeast Missouri Luxury Hotels
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Featured Southeast Missouri Luxury Hotels

Super 8 by Wyndham Pevely
1711 Highway Z, Pevely, MO
At Super 8 by Wyndham Pevely, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. The 24-hour front desk has staff always at the ready. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included

Motel 6 Poplar Bluff, MO
4101 Highway 67 N, Poplar Bluff, MO
Free Cancellation
Reserve now, pay when you stay
The price is $83 per night
$83
includes taxes & fees
$79 per night
Apr 27 - Apr 28
Guests staying at Motel 6 Poplar Bluff, MO enjoy free WiFi in public areas, laundry facilities, and a vending machine. You can take advantage of free parking if you drive. The front desk is staffed 24 hours a day to help with tours/tickets and luggage storage.
Pet friendly
Parking included

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
The price is $92 per night
$92
includes taxes & fees
$81 per night
Apr 27 - Apr 28
Renovated in 2023, Days Inn and Suites by Wyndham Sikeston offers a gym, free WiFi in public areas, and meeting rooms. Free parking is included with your stay. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a library, laundry facilities, and a vending machine.
Breakfast included
Pet friendly

Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Guests of this apartment enjoy access to a water park, laundry facilities, and barbecue grills.
Kitchen
Washer

Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
The price is $66 per night
$66
includes taxes & fees
$58 per night
Apr 28 - Apr 29
Pear Tree Inn Cape Girardeau Near the Medical Center features free WiFi in public areas, a seasonal outdoor pool, and coffee in a common area. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include express check-out and a TV in a common area.
Pool
Pet friendly

Comfort Inn Festus - St Louis South
1303 Veterans Blvd, Festus, MO
Free Cancellation
Reserve now, pay when you stay
The price is $104 per night
$104
includes taxes & fees
$91 per night
Apr 28 - Apr 29
At Comfort Inn Festus - St Louis South, guests have access to a gym, free WiFi in public areas, and a business center. Free parking is included with your stay. Front-desk staff can answer questions 24/7, and assist with tours or tickets, dry cleaning/laundry, and securing valuables. Additional amenities include free newspapers, laundry facilities, and a gift shop.
Breakfast included
Parking included

Super 8 by Wyndham Poplar Bluff Missouri
2831 N Westwood Blvd, Poplar Bluff, MO
Free Cancellation
Reserve now, pay when you stay
The price is $72 per night
$72
includes taxes & fees
$64 per night
May 1 - May 2
Guests of Super 8 by Wyndham Poplar Bluff Missouri enjoy free WiFi in public areas, a 24-hour business center, and laundry facilities. There's free parking if you drive. The 24-hour front desk has staff standing by to help with securing valuables and dry cleaning/laundry. Additional amenities include a picnic area, a vending machine, and an ATM.
Breakfast included
Pet friendly

Quality Inn Festus
1200 W Gannon Dr, Festus, MO
At Quality Inn Festus, guests enjoy an indoor pool, a gym, and free WiFi in public areas. There's free parking and a free beach shuttle. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Other amenities at this family-friendly hotel include conference space, a 24-hour business center, and coffee/tea in a common area.
Pool
Breakfast included

Quality Inn
2011 North Kingshighway, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
The price is $79 per night
$79
includes taxes & fees
$70 per night
May 7 - May 8
Guests of Quality Inn enjoy features like an outdoor pool, free WiFi in public areas, and a computer station. If you decide to drive, there's free parking. The 24-hour front desk has staff always at the ready. Additional amenities include laundry facilities, a TV in a common area, and a vending machine.
Pool
Breakfast included

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
The price is $114 per night
$114
includes taxes & fees
$99 per night
May 4 - May 5
Drury Inn & Suites Sikeston, MO features an indoor pool, an outdoor pool, and a gym. If you drive, put free parking to good use. The front desk is staffed 24/7 to help with dry cleaning/laundry, luggage storage, and securing valuables. Additional amenities include free WiFi in public areas, meeting rooms, and a business center.
Pool
Breakfast included

Drury Inn & Suites Cape Girardeau
3303 Campster Drive, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
The price is $112 per night
$112
includes taxes & fees
$99 per night
May 6 - May 7
Guests of Drury Inn & Suites Cape Girardeau have access to an indoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The 24-hour front desk has staff standing by to help with luggage storage and securing valuables. Additional amenities include a hot tub, meeting rooms, and a business center.
Pool
Hot Tub
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See all available properties in Southeast Missouri
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Southeast Missouri hotels essential information
Accommodation | 561 hotels |
---|---|
Lowest Price | $66 |
Highest Price | $114 |
Popular hotels | Super 8 by Wyndham Pevely, Motel 6 Poplar Bluff, MO, Days Inn and Suites by Wyndham Sikeston, Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Pear Tree Inn Cape Girardeau Near the Medical Center, Comfort Inn Festus - St Louis South, Super 8 by Wyndham Poplar Bluff Missouri, Quality Inn Festus, Quality Inn, Drury Inn & Suites Sikeston, MO, Drury Inn & Suites Cape Girardeau |
Recent Luxury Hotels Reviews

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
5/5 Excellent
"Front desk was super helpful at check in and very courteous throughout the whole stay"
A verified traveler stayed at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Posted 14 hours ago
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