Panama City Vacation Homes

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Featured Vacation Homes in Panama City

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in Panama City

    Hotel Riu Plaza Panama

    Hotel Riu Plaza Panama

    Calle 50, Urb. Marbella, Panama City, Panama
    The price is $127 per night from Dec 23 to Dec 24
    $127
    includes taxes & fees
    $115 per night
    Dec 23 - Dec 24
    9/10 Wonderful! (3,420 reviews)
    Decapolis Hotel Panama City

    Decapolis Hotel Panama City

    Avenida Balboa Con Multicentro, Panama City, Panama
    The price is $90 per night from Jan 4 to Jan 5
    $90
    includes taxes & fees
    $82 per night
    Jan 4 - Jan 5, 2025
    8.4/10 Very Good! (1,004 reviews)
    Plaza Paitilla Inn Hotel

    Plaza Paitilla Inn Hotel

    Italy Avenue, Punta Paitilla, Winston Churchill Street, Panama City, Panama
    The price is $98 per night from Jan 5 to Jan 6
    $98
    includes taxes & fees
    $90 per night
    Jan 5 - Jan 6, 2025
    9.2/10 Wonderful! (1,715 reviews)

Panama City Vacation Homes

Book vacation homes in Panama City
Next time you take a group getaway top Panama City, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of Panama City vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every Panama City vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in Panama City; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a Panama City rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to Panama City is sure to be a winner.

Panama City Vacation Homes essential information

Accommodation
53 Vacation Homes
Lowest Price
$55
Highest Price
$914
Popular accommodation
Charming Maison 4Bdr + 4Bth in Historic Center of Casco Viejo, Oasis with pool near panama canal, Tropical House with Historic Charm, WiFi, Private Bathrooms and Workspaces, Breathtaking Views Mansion w/King Beds, House in Punta Paitilla, Private Vacation Home: Pool, BBQ and more, Panama City economic room, Two Floors Duplex in the middle of Panama City., King Beds 4br Urban Oasis w/ Coffee bar