St. Louis Vacation Homes

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Featured Vacation Homes in St. Louis

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in St. Louis

    Hyatt Regency St. Louis at The Arch

    Hyatt Regency St. Louis at The Arch

    315 Chestnut St, St. Louis, MO
    The price is $149 per night from Jun 15 to Jun 16
    $149
    per night
    Jun 15 - Jun 16
    8.4/10 Very Good! (3,071 reviews)
    Pear Tree Inn St. Louis Airport

    Pear Tree Inn St. Louis Airport

    10810 Pear Tree Ln, St. Ann, MO
    The price is $99 per night from Jun 10 to Jun 11
    $99
    per night
    Jun 10 - Jun 11
    9.2/10 Wonderful! (2,446 reviews)
    Clayton Plaza Hotel & Extended Stay

    Clayton Plaza Hotel & Extended Stay

    7750 Carondelet Avenue, St. Louis, MO
    The price is $105 per night from Jun 9 to Jun 10
    $105
    per night
    Jun 9 - Jun 10
    8.8/10 Excellent! (2,900 reviews)

St. Louis Vacation Homes

Book vacation homes in St. Louis
Next time you take a group getaway top St. Louis, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of St. Louis vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every St. Louis vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in St. Louis; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a St. Louis rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to St. Louis is sure to be a winner.

St. Louis Vacation Homes essential information

Accommodation
653 Vacation Homes
Lowest Price
$49
Highest Price
$149
Popular accommodation
Stunning Townhome in The Grove - 918, Funky mini loft in fox park! Pet friendly!!, 🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟, Entire Dogtown House near Zoo, Forest Park and Wash U, Beautiful, Brand New Tower Grove Unit! 1s, 715a - Settle into Soulard! 4 beds 2 full baths, Stunning Townhome 916 in The Grove, 717a - Settle into Soulard! 6 Q beds, 2 full baths, ☆BackYard BBQ Hidden Gem☆Perfect Location~Groups /Pets Welcome